Brain Death, Organ Donation and Transplantation

Description

This book analyses the impact of organ transplantation. It also presents new, original analyses of data, and assessesmedical practices, social and economic observations, and other information on: access to transplantation services for low-income populations and racial and ethnic minority groups; organ donation rates; waiting times for transplantation; patientsurvival rates and organ failure rates leading to retransplantation; and cost of organ transplantation services. It includeschapters on the possibilities of expanding the pool of available cadaver organs. It also analyzes the results oftransplantation of cadaver organs from older donors and marginal, non-heart beating donors. Transplantation policiesbased on the offering of organs by living donors are also described, as is the impact of delayed graft function on organallocation.

About the author:

Anna Teresa Mazzeo is Associate Professor of Anesthesia and Intensive care at University of Messina, Italy. Previously served at University of Torino, Molinette Hospital, Italy.

Deepak Gupta is Professor of Neurosurgery at Neurosciences Centre & Associated JPN Apex trauma Centre, All India Institute of Medical Sciences. Adjunct Faculty, Indian Institute of technology (IIT) New Delhi, India

Table of contents

Preface
Introduction
Section 1. The diagnosis of brain death
1. Harbingers of Brain Death (Tandon PN)
2. Brain death: history of the concept and implications for organ donation (Pandya SK)
3. Determination of Death by Neurological Criteria (Brain death) (Procaccio F, Munari M)
4. Facing brain death: prelude to brain death diagnosis and testing (Close LN, O'Phelan K, Bullock MR)
5. Pathophysiology and mechanisms of brain death in adults (Carbonara M, Caccioppola A, Stocchetti N)
6. Histology and pathology of brain death (Sengar K, Subramanian A)
7. Neuroimaging of brain death (Veeramani M)
8. The role of neurophysiology (Montalenti E, Costa P)
9. The role of cerebral blood flow studies (Mazzeo AT, Veglia S, Garabello D, Gupta D)
10. The role of transcranial doppler (Conti A)
11. Determination of Neurologic Death in Infants and Children (Nakagawa TA, Pattisapu JV)
12.
Simulation-based training for determination of pediatric brain death (Araki T)
13. Variability of brain death determination around the world: The need for an international consensus (Fossi F, Citerio G)
Section 2. Organ donation all over the world: Challenges and perspectives
14. The Spanish model of organ donation (Badenes R, Della Torre V, Domínguez-Gil B)
15. Organ donation in Europe (Lopez-Fraga M, Dominguez-Gil B)
16. Organ donation in UK (Sharma AK, Halawa A)
17. Organ donation in USA (Sharma A, Ruch B, Russo-Menna I)
18. Organ donation in India: Life after death exists (Gupta D, Singh A, Lalwani S, Sawhney C, Kale SS, Banerji AK)
19. Organ donation in South Africa (Thomson D, Muller E, Du Toit T)
20. Organ donation in Pernambuco and Brazil (Da Cunha AHGB, Da Cunha TEB)
21. Organ donation in Colombia (Pastor L, Montealegre JS, Simmonds N, Mora KD,Vera DS , González-Soto JS, SuarezMN, Rubiano AM)
22. Organ donation in
Australia (Barry L, Opdam H)
23. Organ donation in Saudi Arabia (Shaheen FAM, Shaheen MF, Al Sayyari AA)
24. Organ donation in United Arab Emirates (Alshamsi F, Zaher W, Sankari B, Kumar S, Ibrahim A, Al Yafei ZA, Al MannaeiA, Al Obaidli A)
25. Organ donation in Turkey (Haberal M)
26. Organ donation in Iran (Malek-Hosseini SA, Habibzadeh F)
27. Organ donation in Russia, (Gautier SV, Monakhov A, Tsiroulnikova OM, Khomyakov S, Minina MG, Dzhiner D)
28. Organ donation in China (Li L, Li C, Jiang W, He X)
29. Organ donation in Japan (Kuramitsu K, Egawa H)
Section 3 The organ donor
30. Pathophysiological changes at the moment of brain death (Mazzeo AT, Gupta D)

31. Management of the potential organ donor in the intensive care unit (Mazzeo AT, Urbino R, Potenza R, Puliatti F, GuptaD)
32. Protective mechanical ventilation in the potential organ donor (Costamagna A, Fanelli V, Mascia L)
33. Pharmacological consideration in the
potential organ donor (Dixon R, Medenwald B, Brophy GM)
34. Challenges with organ donation in children (Nakagawa TA, Pattisapu JV)
35. Neonatal organ donation (Coulter C, Brierley J)
36. Infections - A Contraindication to Organ Donation (Halawa A, Sharma AK)
37. Malignancy - A Contraindication to Organ Donation (D'Errico A, Eccher A, Malvi D, Mescoli C, Novelli L)
38. Which tests in the potential multiple organ donor (Genzano Besso F)
39. Clinical risk management in transplantation (Bellandi T)
Section 4. Donor selection, recipient selection and transplantation
40. Preparing for retrieval: the bag, the operating room and the transport of the graft (Costa J, D'Ovidio F)
41. The surgical phases of thoracic organ retrieval (Costa J, D'Ovidio F)
42. The surgical phases of abdominal organs retrieval (Patrono D, Romagnoli R)
43. Anesthesiological management of organ retrieval (Feltracco P, Carollo C, Barbieri S)
44. Heart
transplantation (Saddoughi S, Khullar V, Daly RC)
45. Lung transplantation (Boffini M, Barbero C, Ricci D, Simonato E, Rinaldi M)
46. Ex vivo lung perfusion (Ali A, Cypel M)
47. Liver transplantation (Salizzoni M, Romagnoli R, Tandoi F, Patrono D)
48. Ex vivo liver perfusion (Patrono D, Romagnoli R)
49. Renal transplantation (Kumar N, Kumar A)
50. Pancreas and intestinal transplantation (Samoylova ML, Kesseli SJ, Borle D, Ravindra KV)
51. Ocular tissues: recovery and processing issues (Galeone A, Ferrari S, Sarnicola V, Ponzin D)
52. Skin banks: history, organization and clinical role (Franco P, Castagnoli C, Stella M)
53. Vascularized Composite Allotransplantation (Petruzzo P, Morelon E, Metha P, Testa G)
54. Extracorporeal life support as a bridge to transplantation (Piervincenzi E, Di Nardo M, Pugliese F, Alvarez J, Del SorboL)
55. Donation after circulatory death (Zanierato M, Tardivo S, Brazzi L)
56. Lung donation after
circulatory death (Levvey B, Snell G)
57. Heart donation after circulatory death (Messer S, Large S, Tsui S)
58. Organ donation after circulatory death: abdominal organs with particular reference to liver transplantation (MuiesanP,Lazzeri C,Schlegel A)
59. Indications and outcome of emergency organ transplantation (Boffini M, Barbero C, Ricci D, Simonato E, Patrono D,Romagnoli R, Rinaldi M)
60. Immunosuppression in solid organ transplantation (Lupo F)
61. Common infectious diseases in the recipient (De Rosa FG, Bartoletti M, Corcione S)
62. Psychological support and rehabilitation after transplantation (Biffa G, Golfieri L, Grandi S, Girtler N)
Section 5. Organizational aspects in Organ donation
63. The role of donation and transplantation network (Cardillo M, Procaccio F, Lombardini L, Di Ciaccio P, Nanni Costa A)
64. The role of the Transplant Coordinator (Gomez MP, Valero Castell R, Manyalich Vidal M, Bartolomé RA)
65. The role of
Specialist Nurses in Organ Donation (Rizzato L, Montemurro A)
66. Role of education and training program in organ donation (Coll A, Ballesté C, Blanco C, Vera E, Quiralte A, Valero R,Manyalich M)
67. The Impact of Telehealth in management of Organ Transplantation (Rafiq A, Fei D-Y, Le B, Di Gianbattista C)
68. Communication and organ donation (Pacini A)
Section 6. Ethics and Organ donation
69. The consent to organ donation: Opt-In vs Opt-Out (Gupta D, Mazzeo AT, Mazzeo M)
70. Spiritualism, Ethics in organ transplantation (AK Mahapatra)
71. Conundrums in the definitions of life and death and their ethical implications (Caceres A)
72. Ethics of organ donation in India (Singh D, Wadhwa R, Daljit T)
73. Family members Perspective of Organ Donation: Concerns and Fears (Sethuraman M)
74. Contact between Organ Donor Families and their Recipients is Usually Therapeutic for Both Sides (Green R)
75. Perplexities of contact between
organ donor families and their recipients (Perez Blanco A)
76. Organ donation: an act of Charity (Paglia V)
77. My Transplant Story (Siletto A)
78. Global impact of SARS-CoV2 pandemic on organ donation and transplantation (Mazzeo AT, Gupta D)
5. Contributors
(give full details of major contributors, especially if overseas)